Molecular function and biological importance of CNNM family Mg2+ transporters
نویسندگان
چکیده
منابع مشابه
Insight into renal Mg2+ transporters.
PURPOSE OF REVIEW This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysis and differential gene expression studies have led to the identification of...
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Mg2+ serves as an essential cofactor for numerous enzymes and its levels are tightly regulated by various Mg2+ transporters. Here, we analyzed Caenorhabditis elegans strains carrying mutations in genes encoding cyclin M (CNNM) Mg2+ transporters. We isolated inactivating mutants for each of the five Caenorhabditis elegans cnnm family genes, cnnm-1 through cnnm-5. cnnm-1; cnnm-3 double mutant wor...
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The solute carrier SLC4 family consists of 10 members, nine of which are [Formula: see text] transporters, including three Na(+)-independent Cl(-)/[Formula: see text] exchangers AE1, AE2, and AE3, five Na(+)-coupled [Formula: see text] transporters NBCe1, NBCe2, NBCn1, NBCn2, and NDCBE, as well as "AE4" whose Na(+)-dependence remains controversial. The SLC4 [Formula: see text] transporters play...
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Magnesium (Mg2+) is indispensable for many physiological processes in the cell impacting organ function (de Baaij et al. 2015). Intracellular concentrations of free Mg2+ aremaintained within a narrow range (0.5–1.2 mM) through tightly regulated Mg2+ influx and effluxmechanisms (Ebel & Gunther, 1980). InhibitionofMg2+ effluxby substitution of extracellular Na+ by choline in mammalian cells indic...
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The UPF0016 family is a group of uncharacterized membrane proteins, well conserved through evolution and defined by the presence of one or two copies of an E-Φ-G-D-(KR)-(ST) consensus motif. Our previous results have shown that two members of this family, the human TMEM165 and the budding yeast Gdt1p, are functionally related and might form a new group of cation/Ca2+ exchangers. Most members of...
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ژورنال
عنوان ژورنال: The Journal of Biochemistry
سال: 2018
ISSN: 0021-924X,1756-2651
DOI: 10.1093/jb/mvy095